Healthcare providers and patients taking warfarin must be aware of the potential hazard of using topical methyl salicylate in combination with warfarin.

This is one of the few instances where the synthetic oil is preferred. The genuine oil contains undesirable constituents.

Methyl Salicilate is toxic especially when taken internally. It should be diluted and used in moderation.

Do not apply near the eyes, mouth, nose, or genitals, and be careful not to touch those areas while the medication is on your hands. If you do get the medication in those areas, flush with plenty of water. Wash your hands well before inserting contact lenses.

Apply a thin layer of medication to the affected area no more than 3 to 4 times a day. Rub in gently and thoroughly. After applying the medication, wash your hands unless you are using this medication to treat the hands. If treating the hands, wait at least 30 minutes after applying the medication to wash your hands.

Do not apply this medication to skin that is injured or irritated (e.g., cut, scraped, sunburned). Do not bandage or tightly wrap the affected area. Doing so may increase the risk of side effects. You may cover the area loosely to protect clothing.

Heat can increase the risk of side effects. Do not apply this medication immediately before, during, or after activities that increase skin temperature (e.g., bathing in hot water, swimming, sun bathing, heavy exercise) or in hot/humid weather. Wait until your skin has cooled before applying the medication. Do not use a sunlamp/tanning bed, hot water bottle, or heating pad on the treated area.