This herb is toxic, do not overdose.
Because of its toxic properties, java brucea should not be taken by women who are pregnant or breastfeeding, nor should it be given to small children. In addition, it should not be taken by patients with nausea and vomiting, or those with pre-existing liver or kidney disorders.

As of this writing, there are no known drug interactions associated with java brucea. As always, make sure to consult with a licensed health care provider before taking java brucea or any other herbal remedy or dietary supplement.
Use only with acute symptoms, and stop administration as soon as symptoms are alleviated.

Do not take long term nor in large doses.
Contraindicated for those with pre-existing gastrointestinal bleeding.
Contraindicated for those with pre-existing Liver disease.
Contraindicated for those with pre-existing Kidney disease.
Contraindicated during pregnancy and nursing.
Contraindicated for young children.